More than 67,300 Americans died from drug-involved overdose in 2018, including illicit drugs and prescription opioids. The figure above is a bar and line graph showing the total number of U.S. drug overdose deaths involving any illicit or prescription opioid drug from 1999 to 2018. Drug overdose deaths rose from 38,329 in 2010 to 70,237 in 2017; followed by a significant decrease in 2018 to 67,367 deaths. The bars are overlaid by lines showing the number of deaths by gender from 1999 to 2018 (Source: CDC WONDER).

Source: NIH.GOV